Table 1.
The association between patient characteristics and HBV-related HCC risk
| Variables | Total number of HBV patients (%) |
HCC patients (%) | Univariate |
Multivariate* |
|||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age | |||||||
| ≤ Median | 432 (50.5) | 18 (22.0) | 1.00 | 1.00 | |||
| > Median | 423 (49.5) | 64 (78.0) | 5.29(3.12-8.98) | 6.7 × 10−10 | 4.59(2.68-7.89) | 3.2 × 10−8 | |
| Gender | |||||||
| Female | 295 (34.5) | 11 (13.4) | 1.00 | 1.00 | |||
| Male | 560 (65.5) | 71 (86.6) | 2.83(1.50-5.34) | 0.001 | 2.40(1.18-4.87) | 0.015 | |
| Smoking status | |||||||
| Never smokers | 580 (67.8) | 38 (46.3) | 1.00 | 1.00 | |||
| Ever smokers | 275 (32.2) | 44 (53.7) | 2.60(1.67-4.03) | 2.0 × 10−5 | 2.01(1.15-3.54) | 0.015 | |
| Drinking status | |||||||
| Never drinkers | 534 (62.5) | 41 (50.0) | 1.00 | 1.00 | |||
| Ever drinkers | 321 (37.5) | 41 (50.0) | 2.01(1.29-3.12) | 0.002 | 0.94(0.54-1.64) | 0.831 | |
| Family history of cancer | |||||||
| No | 555 (64.9) | 46 (56.1) | 1.00 | 1.00 | |||
| Yes | 300 (35.1) | 36 (43.9) | 1.66(1.07-2.57) | 0.024 | 1.21(0.77-1.90) | 0.417 | |
| Cirrhosis | |||||||
| No | 570 (66.7) | 16 (19.5) | 1.00 | 1.00 | |||
| Yes | 285 (33.3) | 66 (80.5) | 6.99(4.04-12.09) | 3.4 × 10−12 | 4.22(2.42-7.36) | 4.0 × 10−7 | |
*
Adjusted for age, gender, smoking and drinking status, family history of cancer, and cirrhosis, where appropriate.