Table 2.

The association between APRI and HCC risk

APRI values	Total number of HBV patients	HCC cases	Univariate analysis		Multivariate analysis*		Multivariate analysis†		Log-rank P
			HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
In patients with a 1-year exclusion window (n=855)
By median
≤ Median	429	24	1.00		1.00		1.00		1.6 × 10−5
> Median	426	58	2.75(1.70-4.43)	3.4 × 10−5	1.60(0.95-2.70)	0.076	2.27 (1.39-3.72)	0.001
By quartile
1st quartile	211	5	1.00		1.00		1.00		1.9 × 10−6
2nd quartile	218	19	4.05(1.51-10.85)	0.005	1.92(0.70-5.27)	0.203	2.31 (0.85-6.30)	0.102
3rd quartile	212	26	5.31(2.04-13.84)	0.001	2.26(0.84-6.12)	0.108	3.29 (1.24-8.70)	0.017
4th quartile	214	32	8.93(3.46-23.04)	5.9 × 10−6	3.00(1.11-8.09)	0.03	5.21 (1.98-13.71)	8.2 × 10−4
P trend				2.9 × 10−7		0.021		7.1 × 10−5
In patients with a 2-year exclusion window (n=686)
By median
≤ Median	342	16	1.00		1.00		1.00		3.1 × 10-5
> Median	344	44	3.18(1.79-5.66)	8.0 x10−5	2.04(1.10-3.79)	0.023	2.79 (1.54-5.03)	6.8 × 10−4
By quartile
1st quartile	174	4	1.00		1.00		1.00		1.9 × 10−5
2nd quartile	168	12	3.38(1.09-10.51)	0.035	1.72(0.54-5.46)	0.359	2.09 (0.66-6.60)	0.210
3rd quartile	172	20	5.26(1.79-15.41)	0.002	2.54(0.83-7.77)	0.102	3.54 (1.18-10.58)	0.024
4th quartile	172	24	8.93(3.08-25.89)	5.5 × 10−5	3.55(1.17-10.78)	0.026	6.05 (2.04-17.92)	0.001
P trend				2.8 × 10−6		0.008		6.3 × 10−5

^*Adjusted for age, gender, smoking and drinking status, family history of cancer, and cirrhosis.

^†Adjusted for age, gender, smoking and drinking status, and family history of cancer.