Table 3.

The association between APRI and HCC risk stratified by patients’ characteristics

Variables	APRI values	Number of patients	HCC cases	Univariate		Multivariate*
				HR (95% CI)	P value	HR (95% CI)	P value
Age
Younger (≤ Median)
	≤ Median	256	8	1.00		1.00
	> Median	176	10	1.93(0.76-4.92)	0.166	2.87(1.00-8.27)	0.050
Older (> Median)
	≤ Median	173	16	1.00		1.00
	> Median	250	48	2.37(1.34-4.19)	0.003	1.46(0.78-2.75)	0.239
Gender
Female
	≤ Median	160	2	1.00		1.00
	> Median	135	9	6.27(1.35-29.17)	0.019	2.74(0.53-14.22)	0.232
Male
	≤ Median	269	22	1.00		1.00
	> Median	291	49	2.35(1.42-3.90)	0.001	1.56(0.90-2.7)	0.117
Smoking status
Never smokers
	≤ Median	303	10	1.00		1.00
	> Median	277	28	3.03(1.46-6.26)	0.003	1.19(0.54-2.66)	0.664
Ever smokers
	≤ Median	126	14	1.00		1.00
	> Median	149	30	2.79(1.44-5.38)	0.002	2.09(1.04-4.24)	0.040
Drinking status
Never drinkers
	≤ Median	271	10	1.00		1.00
	> Median	263	31	3.28(1.60-6.73)	0.001	1.3(0.58-2.90)	0.518
Ever drinkers
	≤ Median	158	14	1.00		1.00
	> Median	163	27	2.49(1.27-4.85)	0.008	2.24(1.08-4.63)	0.029
Family history of cancer
No
	≤ Median	271	14	1.00		1.00
	> Median	284	32	2.46(1.31-4.63)	0.005	1.57(0.79-3.12)	0.194
Yes
	≤ Median	158	10	1.00		1.00
	> Median	142	26	3.53(1.65-7.55)	0.001	2.19(0.93-5.14)	0.073
Cirrhosis
No
	≤ Median	355	8	1.00		1.00
	> Median	215	8	1.52(0.55-4.19)	0.422	1.53(0.5-4.68)	0.453
Yes
	≤ Median	74	16	1.00		1.00
	> Median	211	50	1.97(1.11-3.5)	0.020	1.76(0.95-3.26)	0.074

^*Adjusted for age, gender, smoking and drinking status, family history of cancer, and cirrhosis, where appropriate.