. Author manuscript; available in PMC: 2015 May 4.

Published in final edited form as: Dalton Trans. 2008 Nov 4;(1):177–184. doi: 10.1039/b808831d

Table 1.

Biodistribution (percent dose per gram, %ID/g) of [⁶⁴Cu(NEC-SE)] (7), [⁶⁴Cu(NEC-SP)] (8) and [⁶⁴Cu(NEC-SB)] (9) in male Lewis rats. Rats were injected with ~40 μCi of complex and were euthanized at 3 time points (n = 4 per group at 1, 4 and 24 h). Following euthanasia, 19 tissues and organs of interest were removed and weighed and the radioactivity present was measured in a γ-counter. Given are the %ID/g values for selected organs. The complete biodistribution data for all 19 tissues, including percent dose per organ (%ID/organ) values, can be found in the ESI^†

	[⁶⁴Cu(NEC-SE)] (7), %ID/g			[⁶⁴Cu(NEC-SP)] (8), %ID/g			[⁶⁴Cu(NEC-SB)] (9), %ID/g
Tissue	1 h	4 h	24 h	1 h	4 h	24 h	1 h	4 h	24 h
Blood	0.850 ± 0.051	0.897 ± 0.080	0.768 ± 0.040	0.820 ± 0.046	0.835 ± 0.021	0.774 ± 0.031	0.874 ± 0.140	0.879 ± 0.112	0.692 ± 0.151
Lung	0.838 ± 0.065	0.768 ± 0.045	0.723 ± 0.036	0.776 ± 0.089	0.737 ± 0.009	0.771 ± 0.061	1.673 ± 0.225	0.949 ± 0.109	0.746 ± 0.143
Liver	3.919 ± 0.363	3.905 ± 0.540	3.314 ± 0.476	3.151 ± 0.286	3.418 ± 0.371	3.182 ± 0.188	4.105 ± 0.465	3.866 ± 0.635	3.296 ± 0.728
Spleen	0.560 ± 0.025	0.731 ± 0.174	1.046 ± 0.106	0.483 ± 0.054	0.704 ± 0.014	1.078 ± 0.099	0.698 ± 0.168	0.815 ± 0.137	0.924 ± 0.207
Kidney	8.662 ± 0.551	7.849 ± 1.099	4.906 ± 0.211	9.438 ± 1.019	7.818 ± 0.663	5.070 ± 0.518	8.895 ± 0.612	7.096 ± 1.059	4.738 ± 0.617
Muscle	0.380 ± 0.032	0.344 ± 0.012	0.309 ± 0.026	0.393 ± 0.055	0.352 ± 0.017	0.319 ± 0.031	0.411 ± 0.056	0.330 ± 0.050	0.302 ± 0.033
Fat	0.334 ± 0.054	0.266 ± 0.068	0.163 ± 0.026	0.318 ± 0.074	0.214 ± 0.024	0.153 ± 0.019	0.371 ± 0.073	0.218 ± 0.037	0.136 ± 0.035
Heart	0.672 ± 0.086	0.774 ± 0.096	1.041 ± 0.070	0.657 ± 0.025	0.736 ± 0.048	1.013 ± 0.078	0.839 ± 0.228	0.752 ± 0.059	0.923 ± 0.189
Bone	1.131 ± 0.072	1.274 ± 0.082	0.984 ± 0.076	1.099 ± 0.098	1.255 ± 0.040	0.999 ± 0.065	1.143 ± 0.195	1.155 ± 0.161	0.855 ± 0.188