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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Bioessays. 2014 Oct 27;37(1):12–19. doi: 10.1002/bies.201400106

Figure 3.

Figure 3

Two pathways of cellular TCR. UvrD-dependent TCR (left). Under conditions of massive DNA damage, the SOS response increases UvrD output, which leads to UvrD dimerization, RNAP backtracking, and TCR.Mfd-dependent TCR (right). Cells with a steady-state level of DNA damage have low concentrations of UvrD, thus the UvrD-dependent pathway is repressed. DNA damage is located and removed via Mfd-dependent TCR. Proposed switch from Mfd to UvrD pathway under non-SOS stress conditions is shown by the dashed line.