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Model for centromeric identity, maintenance and function through a two-step mechanism. In the first step centromere identity is achieved by the CATD-containing chromatin through its loading mediated by HJURP at the mitotic exit. Subsequently, new and old CENP-A can nucleate kinetochore assembly on the CATD chromatin through the action of the CENP-A’s amino tail that stabilize CENP-B and by the direct recruitment of CENP-C by the carboxy tail of CENP-A.
