. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: J Mol Cell Cardiol. 2014 Apr 18;72:305–315. doi: 10.1016/j.yjmcc.2014.04.006

Table 1.

Echocardiography and pathology of WT and Nrf2^ctg after TAC.

(n)	WT		Nrf2^ctg
	Sham	TAC	Sham	TAC
Echocardiography	(11)	(10)	(11)	(10)
LVID;d (mm)	3.83 ± 0.34	3.60 ± 0.32	3.57 ± 0.38	3.32 ± 0.20
LVID;s (mm)	2.18 ± 0.48	2.63 ± 0.30^A	2.17 ± 0.33	2.18 ± 0.20^C
LVPW;d (mm)	0.81 ± 0.13	1.37 ± 0.15^A	0.93 ± 0.08	1.20 ± 0.10^B ^C
FS (%)	42.90 ± 5.20	27.26 ± 2.79^A	39.25 ± 2.19	33.89 ± 3.02^B ^C
EF (%)	74.43 ±3.97	53.82 ± 7.38^A	70.68 ± 1.65	63.51 ± 8.79^B ^C
Pathology	(11)	(10)	(11)	(10)
BW (g)	29.75 ± 1.49	28.55 ± 0.89	26.15 ± 1.21	27.45 ± 0.75
HW/Tibia (g/cm)	0.12 ± 0.01	0.20 ± 0.03^A	0.10 ± 0.01	0.15 ± 0.02^B ^C
LW/Tibia (g/cm)	0.10 ± 0.01	0.23 ± 0.06^A	0.09 ± 0.01	0.11 ± 0.01^C
MC CSA (µm²)	298.4 ± 21.5 (7)	524.0 ± 65.9^A (7)	264.9 ± 39.8 (7)	441.7 ± 47.5^B ^C (7)
Fibrosis (%area)
LV	0.80 ± 0.23 (7)	25.43 ± 6.80^A (7)	0.45 ± 0.13 (7)	10.86 ± 3.54^B ^C (7)
IVS	0.80 ± 0.20 (7)	12.01 ± 2.77^A (7)	0.64 ± 0.15 (7)	4.71 ± 1.47^B ^C (7)
RV	1.19 ± 0.42 (7)	11.31 ± 4.76^A (7)	0.61 ± 0.34 (7)	4.51 ± 2.41^B ^C (7)
TUNEL (% cells)	0.06 ± 0.01 (7)	0.49 ± 0.07^A (7)	0.08 ± 0.03 (7)	0.12 ± 0.03^B ^C (7)
mRNAs	(5)	(4)	(5)	(4)
ANF	1.03 ± 0.24	9.09 ± 2.90^A	0.97 ± 0.27	4.78 ± 0.41^B ^C
BNP	1.13 ± 0.28	3.16 ± 0.69^A	0.82 ± 0.23	1.78 ± 0.73^B ^C
αMHC	0.95 ±0.13	0.61 ± 0.08^A	0.99 ± 0.07	0.80 ± 0.08^B ^C
βMHC	1.00 ± 0.27	3.96 ± 0.09^A	0.92 ± 0.09	2.43 ± 0.33^B ^C
SERCA	1.07 ± 0.15	0.61 ± 0.12^A	1.13 ± 0.17	0.85 ± 0.09^B

Littermates of male WT and Nrf2^ctg mice at ages of 8–10 weeks were subjected to sham and TAC operations. LVID;d, left ventricular internal dimension diastolic; LVID;s, left ventricular internal dimension systolic; LVPW;d, left ventricular posterior wall diastolic; FS, fractional shortening; BW, body weight; HW/BW, heart weight/body weight ratio; MCCSA, left ventricular myocyte cross-sectional area; Lung wt/BW, lung weight/body weight ratio; LV, left ventricle; IVS, interventricular septum; RV, right ventricle; ANF, atrial natriuretic factor; BNP, brain natriuretic factor; βMHC, beta-myosin heavy chain; αMHC, alphamyosin heavy chain; SERCA, sarcoplasmic reticulum calcium ATPase2a. Animal numbers for each group are indicated in the parentheses.

p < 0.05 vs WT sham;

p < 0.05 vs Nrf2^ctg sham;

p < 0.05 vs WT TAC.