Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2015 May 4.

Published in final edited form as: Dev Dyn. 2014 Jan 4;243(4):601–611. doi: 10.1002/dvdy.24100

Schematics depicting the expression profiles of class II SLRPs from E14.5 to adult in the A pulmonary valve and the arterial wall of the pulmonary artery, B aortic valve and aortic wall, and C the mitral valve. Images depict the summary of the IHC patterns for biglycan (BGN, purple), decorin (DCN, green), fibromodulin (FMOD, red) and lumican (LUM, blue). The general trends of IHC intensity are depicted by the shades of individual colors, i.e. dark shades equal high signal intensity and light shades indicate lighter signal intensity. Orange rectangles-regions where valve cusps anchor at the base of the ventricles; orange squares-regions where cusps anchor within the arterial walls; *-staining within the annulus associated with the AC cusp of the pulmonary valve (PV). PA-pulmonary artery; RC-right cusp of the PV; AC-anterior cusp of the PV; LC-left cusp of the PV; Ao-arterial wall of the aortic artery; AV- aortic valve; RCC-right coronary cusp of the AV; LCC-left coronary cusp of the AV; MV-mitral valve; AL-anterior leaflet of the MV; PL-posterior leaflet of the MV; LV-left ventricle; LA-left atrium; CT-chordae tendineae. Open arrow- localization in the prevalvular mesenchyme adjacent to the myocardium; solid arrow-staining within the myocardium adjacent to the valve mesenchyme; open arrowheads- staining within the base of the MV; solid arrowheads-staining within the tip of the MV; -denotes ventricular myocardium; -denotes atrial myocardium.

Schematics depicting the expression profiles of class II SLRPs from E14.5 to adult in the A pulmonary valve and the arterial wall of the pulmonary artery, B aortic valve and aortic wall, and C the mitral valve. Images depict the summary of the IHC patterns for biglycan (BGN, purple), decorin (DCN, green), fibromodulin (FMOD, red) and lumican (LUM, blue). The general trends of IHC intensity are depicted by the shades of individual colors, i.e. dark shades equal high signal intensity and light shades indicate lighter signal intensity. Orange rectangles-regions where valve cusps anchor at the base of the ventricles; orange squares-regions where cusps anchor within the arterial walls; *-staining within the annulus associated with the AC cusp of the pulmonary valve (PV). PA-pulmonary artery; RC-right cusp of the PV; AC-anterior cusp of the PV; LC-left cusp of the PV; Ao-arterial wall of the aortic artery; AV- aortic valve; RCC-right coronary cusp of the AV; LCC-left coronary cusp of the AV; MV-mitral valve; AL-anterior leaflet of the MV; PL-posterior leaflet of the MV; LV-left ventricle; LA-left atrium; CT-chordae tendineae. Open arrow- localization in the prevalvular mesenchyme adjacent to the myocardium; solid arrow-staining within the myocardium adjacent to the valve mesenchyme; open arrowheads- staining within the base of the MV; solid arrowheads-staining within the tip of the MV; -denotes ventricular myocardium; -denotes atrial myocardium.