Table 2.

Meta-analysis of antipsychotic-induced changes in peripheral leptin levels

Comparison	Study arms, n	Hedges g	Variance	95% CI	P
Clozapine	4	0.570	0.049	0.137 to 1.003	0.01
Haloperidol	3	0.423	0.06	−0.056 to 0.902	0.08
Mixed antipsychotics	8	0.431	0.022	0.142 to 0.721	0.004
Olanzapine	17	0.649	0.012	0.439 to 0.859	<0.001
Quetiapine	2	0.790	0.096	0.182 to 1.398	0.01
Risperidone	5	0.285	0.035	−0.083 to 0.652	0.13
Composite	39	0.533	0.005	0.397 to 0.668	<0.001
Sample
Plasma	15	0.525	0.011	0.315 to 0.734	<0.001
Serum	24	0.534	0.007	0.367 to 0.701	<0.001
Baseline drug treatment
Antipsychotic	9	0.249	0.014	0.019 to 0.479	0.03
Drug-free	16	0.613	0.008	0.433 to 0.793	<0.001
Drug-naive	8	0.707	0.014	0.472 to 0.942	<0.001
Not specified	6	0.421	0.021	0.133 to 0.708	0.004
Study quality
Single arm	24	0.515	0.007	0.348 to 0.682	<0.001
Randomized	15	0.553	0.011	0.345 to 0.762	<0.001