Table 3.

Meta-regression analyses of the relations between changes in leptin levels during treatment and other clinical variables

Clinical variable	Study arms, n	Slope (β)	P
Study length, weeks	39	0.00422	0.04a
Age of patients, years	37	−0.04028	<0.001
Sex, % of male patients	36	−0.00022	0.85
Changes in body mass index	37	0.21324	<0.001
Changes in glucose levelsb	13	−0.03050	<0.001
Changes in HDL levels	14	−0.03886	0.03a
Changes in LDL levels	14	0.02816	<0.001
Changes in insulin levels	13	−0.01586	0.04a
Changes in total cholesterol levels	13	0.03537	<0.001
Changes in triglycerides levels	18	0.00948	<0.001

HDL = high-density lipoprotein; LDL = low-density lipoprotein

^aNonsignificant after applying Bonferoni correction

^bFor metabolic markers, standard international units were used