Table 5. LD50 (Mean±SD) of four compounds with different polarities in zebrafish and rodent.
Drug (LogP) | Zebrafish | Zebrafish (chorion torn) | Rodent a | ||
---|---|---|---|---|---|
6-hpf (mg/mL) | 3-dpf (mg/mL) | 6-hpf (μg/mL) | Mouse (mg/kg) | Rat (mg/kg) | |
Ceftazidime (0.4) | 30.3±3.6 | 3.9±1.7 | 7.0±0.8 | 6,300 | 6,100 |
Minocycline (-0.6) | 0.21±0.2 | 0.23±0.1 | 3.0±1.1 | 154 | 164 |
Cefotaxime (-1.4) | 23.9±3.9 | 2.1±1.4 | 6.2±1.5 | 6,845 | 7,000 |
Netilmicin (-4.3) | 11.2±2.5 | 0.19±0.1 | 2.3±1.2 | 40 | 25 |