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. 2015 May 4;10(5):e0124805. doi: 10.1371/journal.pone.0124805

Table 5. LD50 (Mean±SD) of four compounds with different polarities in zebrafish and rodent.

Drug (LogP) Zebrafish Zebrafish (chorion torn) Rodent a
6-hpf (mg/mL) 3-dpf (mg/mL) 6-hpf (μg/mL) Mouse (mg/kg) Rat (mg/kg)
Ceftazidime (0.4) 30.3±3.6 3.9±1.7 7.0±0.8 6,300 6,100
Minocycline (-0.6) 0.21±0.2 0.23±0.1 3.0±1.1 154 164
Cefotaxime (-1.4) 23.9±3.9 2.1±1.4 6.2±1.5 6,845 7,000
Netilmicin (-4.3) 11.2±2.5 0.19±0.1 2.3±1.2 40 25

aRodent data reference [4043].