Table 2. Three key miRNAs and their predicted target genes in cancer-related pathways.

Key miRNAs	Target genes
miR-199-5p	ABL1,AKT2,APC,APPL1,BCL2,BID,CBL,CDKN1A,CDKN2B,CEBPA,COL4A4,CRKL,CYCS,E2F2,E2F3,ERBB2,ETS1,FGF23,FGFR1,FZD4,FZD5,FZD6,GLI3,GRB2,IGF1R,ITGA2,ITGA6,KITLG,KRAS,LAMB3,LAMC1,MAPK1,MMP2,PAX8,PIK3R1,PIK3R5,PML,PRKCA,PTCH1,RARA,RUNX1,RXRA,SMAD2,SMAD3,STAT1,STK4,TGFA,TGFBR1,TPM3,TRAF1,VEGFA,WNT4,WNT5A
miR-22	ABL1,AKT2,AKT3,APPL1,BCL2L1,CBL,CDK6,CDKN1A,CEBPA,COL4A4,CRK,CRKL,CYCS,E2F2,ETS1,FAS,FGF23,FGF5,FGFR1,FGFR2,FGFR3,FOXO1,FZD5,FZD6,GLI3,GRB2,IGF1R,LAMC1,MAPK1,MAPK10,MAX,PAX8,PIK3R5,PLD1,PML,PRKCA,PTCH1,RET,RUNX1,RUNX1T1,RXRA,SMAD3,STAT1,STK4,TCF7,TGFBR1,TP53,TPM3,TRAF1,TRAF6,WNT4,WNT5A,XIAP
miR-429	AKT2,AKT3,APPL1,BCL2,CBL,CDC42,CDK6,CDKN1A,CDKN2B,CEBPA,COL4A4,COL4A6,CRK,CRKL,CYCS,E2F3,ETS1,FAS,FGF23,FN1,FOXO1,FZD4,FZD5,FZD6,GLI3,IGF1,ITGA2,KITLG,KRAS,LAMC1,MAPK1,MITF,PIK3R3,PLCG1,PRKCA,PTCH1,RAC1,RET,RUNX1,RXRA,SMAD2,SMAD3,SOS1,STAT1,STK4,TGFBR1,TRAF6,VEGFA,WNT4,WNT5A,XIAP