Figure 4.

Three coronal slices of the integrin β3 (ITGB3) mouse model compared with wild type showing effect size. Smaller volumes (cyan) were found in all vermis lobules (gray and white matter), the trunk of the arbor vita, and the gray and white matter of the simple, crus I, crus II, and copula hemisphere lobules. However, the trunk of the simple and crus I lobules was found to be larger in volume (magenta). All three deep cerebellar nuclei showed bilateral decreases in volume. A positive effect size represents an expansion of the region in the ITGB3 mouse relative to controls, and a negative value represents a contraction in that region of the ITGB3 mouse relative to controls (volumes have been normalized to total brain volume). These changes have been corrected for multiple comparisons using a false discovery rate threshold of 5%.