Table 4. Mean change in eGFR from baseline from individual studies (CG method).
| Primary author—study name | Treatment dose | Mean change from baseline (mL/min) | SD | SE |
|---|---|---|---|---|
| Gallant, 2013[12]—GS-US-216-0114 | ATV/r + TDF/FTC—300/100 + 300/200 mg ¤ | -9.10 * (median) | 13.64 a | 0.73 c |
| ATV/cobi + TDF/FTC—300/150 + 300/200 mg | -12.90 * (median) | 12.45 a | 0.67 c | |
| Elion, 2011[35]—GS-US-216-0105 | ATV/r + TDF/FTC—300/100 + 300/200 mg | -11.00 ** | 17.11 μ | 3.18 c |
| ATV/cobi + TDF/FTC—300/150 + 300/200 mg | -13.00 ** | 12.45 μbis | 1.76 c | |
| Dejesus, 2012[28]—GS-236-0103 | ATV/r + TDF/FTC—300/100 + 300/200 mg | -9.30 * | 16.00 * | 0.85 c |
| EVG/cobi/TDF/FTC—150/150/300/200 mg | -13.30 * | 14.00 * | 0.75 c | |
| Daar, 2011[36]—A5202 | ATV/r + TDF/FTC—300/100 + 300/200 mg | 0.50 * | 21.70 † | 1.09 c |
| EFV + TDF/FTC—600 + 300/200 mg | 4.70 * | 21.40 † | 1.13 c | |
| EFV + ABC/3TC—600 + 600/300 mg | 5.80 * | 20.80 † | 1.13 c | |
| ATV/r + ABC/3TC—300/100 + 600/300 mg | 4.40 * | 23.00 † | 1.18 c | |
| Vrouenraets, 2011[31]—BASIC | ATV/r + TDF/FTC—300/100 + NR mg | -1.00 *** | 46.44 b | 5.95 c |
| SQV/r + TDF/FTC—2,000/100 + NR mg | -10.00 *** | 37.67 b | 4.99 c | |
| Aberg, 2012[21]—METABOLIK | ATV/r + TDF/FTC—300/100 + 300/200 mg | -0.03 * | 0.24 * | 0.04 c |
| DRV/r + TDF/FTC—800/100 + 300/200 mg | 0.00 * | 0.29 * | 0.05 c |
CG: Cockcroft–Gault; eGFR: estimated Glomerular Filtration Rate; NR: Non Reported; SD: Standard Deviation; SE: Standard Error
* Values retrieved from the paper
** Calculated using eGFR at baseline and at 48 weeks
*** Values retrieved graphically and deduced using the difference in the mean change from baseline
a Calculated using the interquartile range and assuming a normal distribution, see Eq (1) in the statistical analysis section
b Calculated using the Eq (2) detailed in the statistical analysis section
c Calculated using the Eq (3) detailed in the statistical analysis section
μ Calculated using the weighted average of the available SD associated with the ATV/r + TDF/FTC arm from Gallant, 2013, Dejesus, 2012 and Daar, 2011 studies
μbis Value estimated by assuming the same SD as the one used in the Gallant, 2013 study for the ATV/cobi + TDF/FTC arm
† Values obtained after contacting the author
¤ Dose retrieved from clinicaltrials.gov (NCT01108510)