Fig. 1.

Creation of 3D topographical maps of molecules and microbes distributed on the human skin. Samples were collected at ∼400 distinct body sites from each of two volunteers. For each sample, detection of molecules was performed using MS (UPLC-QTOF and MALDI-TOF) and bacteria using 16S rRNA amplicon sequencing. After 3D modeling, a map was rendered for each molecular feature and for each taxon detected in each spot on the body sampled. The 3D maps show body distribution of sphingosine and palmitoleic acid in person 1 and person 2, respectively. The data analysis involved integrative analysis of heterogeneous big data followed up by structural biochemical analysis of molecular features of interest. See also Fig. S1.