Table 1.
Liver function and blood tests at baseline and at the development of severe pancytopenia and final outcome
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 (LT) | Case 7 (LT) | |
| Features at baseline | |||||||
| Hemoglobin (g/dL) | 14.3 | 14.2 | 12.9 | 13.5 | 13.4 | 13.9 | 14 |
| Neutrophils (mm3) | 1500 | 1320 | 1900 | 900 | 3810 | 2880 | 1700 |
| Platelets (mm3) | 74000 | 96000 | 108000 | 101000 | 199000 | 102000 | 78000 |
| ALT (IU/L) | 59 | 77 | 46 | 96 | 77 | 120 | 536 |
| Bilirubin (mg/dL) | 1.3 | 0.93 | 0.6 | 1.1 | 0.5 | 1.4 | 1.2 |
| Albumin (g/dL) | 32 | 47 | 37 | 40 | 45 | 35 | 36 |
| INR | 1.1 | 1.1 | 1 | 1 | 1 | 1.1 | 1.28 |
| Liver stiffness (kPa) | 50 | 10.8 | 16 | 11 | 16.8 | 14.2 | 12 |
| HVPG (mmHg) | 16 | - | - | 8.5 | - | 8.5 | - |
| Child-Pugh score | 6 | 5 | 5 | 5 | 5 | 6 | 5 |
| Features at diagnosis of pancytopenia | |||||||
| Triple therapy (wk) | 10 | 4 | 7 | 5 | 16 | 16 | 8 |
| Hemoglobin (g/dL) | 7.5 | 7 | 7.8 | 7.6 | 7.2 | 7.9 | 8.5 |
| Neutrophils (cells/μL) | 400 | 0 | 250 | 200 | 400 | 400 | 300 |
| Platelets (109/L) | 5000 | 19000 | 2400 | 23000 | 12000 | 9000 | 30000 |
| Reticulocytes (109/L) | 0.2% | 0.1% | 0.6% | - | < 1% | < 1% | - |
| Bone Marrow Biopsy | Yes | Yes | Yes | - | - | - | - |
| Specific treatment | |||||||
| Treatment interruption | Yes | Yes | Yes | Yes | No | Yes | Yes |
| Blood transfusion (units) | 14 | 7 | NA | 6 | 20 | 10 | 0 |
| EPO (days of therapy) | 30 | 60 | 60 | 6 | 240 | 90 | 30 |
| GCSF (days of therapy) | 30 | 60 | 30 | 6 | 90 | 90 | 45 |
| Outcome | Death | Recovered | Death | Death | Recovered | Recovered | Recovered |
LT: Liver transplantation; ALT: Alanine aminotransferase; INR: International normalized ratio; HVPG: Hepatic venous pressure gradient; AA: Aplastic anemia; EPO: Erythropoietin; GCSF: Granulocyte colony stimulating factor; NA: Not available.