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Dysregulation of the alternative complement cascade due to acquired or genetic factors leads to defective complement control causing a range of complement-associated glomerulopathies. CFHR3: Complement factor H-related protein 3; MCP: Membrane co-factor protein; CR1: Complement receptor 1; AP: Alternative pathway; CFHR5: Complement factor H-related protein 5; FSGS: Focal segments glomerular sclerosis; MAC: Membrane attack complex.
