Figure 1.

PPARα^Δob/ob mice become super obese. A: Physical appearance of chow-fed 16-month-old wild-type (WT), PPARα^−/−, ob/ob, and PPARα^Δob/ob mice. Acox1^Δob/ob and Acox1^−/− mice that manifest PPARα activation by endogenous ligands are included for comparison. B: Age-related body weight changes of WT, PPARα^−/−, ob/ob, and PPARα^Δob/ob mice, aged 4 to 52 weeks. C: For food consumption estimation, three mice in each group were housed in separate cages, and daily food intake (kcal) per body weight was determined by measuring 7-day consumption. ^∗P < 0.05, ^∗∗P < 0.01 versus WT; ^†P < 0.05, ^††P < 0.01 versus PPARα^−/−; ^‡P < 0.05 versus ob/ob.