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. 2015 May;185(5):1396–1408. doi: 10.1016/j.ajpath.2015.01.018

Figure 7.

Figure 7

Liver cell proliferation and induction of l-3-hydroxyacyl-CoA dehydrogenase (l-PBE) resulting from PPARα activation by dietary Wy-14,643 for 4 days. Bromodeoxyuridine (BrdUrd) labeling (A) and l-PBE immunohistochemical staining (B) of livers of 2-month-old wild-type (WT), PPARα−/−, ob/ob, and PPARαΔob/ob mice fed with chow diet or 0.125% Wy-14,643 for 4 days. Liver/body weight ratio (C) and hepatocyte proliferation (D) assessed by BrdUrd labeling ratio by calculating BrdUrd-positive hepatocyte nuclei.