Table 3.
Genotype distribution of PPARGC1A SNPs by ethnicity and T2D.
| SNPs | Minor allele | Haitian Americans (n = 226) | African Americans (n = 246) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 110) | Controls (n = 116) | P-value | MAF (%) | Cases (n = 124) | Controls (n = 122) | P value | MAF (%) | ||||
| Cases | Controls | Cases | Controls | ||||||||
| Genotype frequencies (n, %) | |||||||||||
| rs8192678 | |||||||||||
| CC | 92 (84) | 102 (88) | 103 (84) | 104 (85) | |||||||
| CT | T | 4 (4) | 14 (12) | 0.000 | 0.145 | 0.060 | 19 (15) | 18 (15) | 0.365 | 0.093 | 0.074 |
| TT | 14 (13) | 0 (0) | 2 (2) | 0 (0) | |||||||
| rs7656250 | |||||||||||
| TT | 85 (73) | 96 (83) | 90 (72) | 98 (80) | |||||||
| CT | C | 24 (22) | 19 (16) | 0.579 | 0.118 | 0.090 | 27 (22) | 21 (17) | 0.263 | 0.165 | 0.110 |
| CC | 1 (0.9) | 1 (0.8) | 7 (6) | 3 (2) | |||||||
| rs4235308 | |||||||||||
| TT | 35 (32) | 52 (45) | 56 (45) | 51 (42) | |||||||
| CT | C | 59 (54) | 52 (45) | 0.124 | 0.441 | 0.327 | 51 (41) | 60 (49) | 0.327 | 0.343 | 0.336 |
| CC | 16 (14) | 12 (10) | 17 (14) | 11 (9) | |||||||
| rs11724368 | |||||||||||
| CC | 93 (84) | 100 (86) | 103 (83) | 105 (86) | |||||||
| CG | G | 17 (15) | 16 (14) | 0.724 | 0.072 | 0.069 | 19 (15) | 17 (14) | 0.347 | 0.093 | 0.069 |
| GG | 0 (0) | 0 (0) | 2 (2) | 0 (0) | |||||||
Note: genotype frequencies are depicted as n (%). Cases: with T2D; controls: without T2D; SNP: single nucleotide polymorphism; MAF: minor allele frequency.