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. 2015 May;185(5):1436–1447. doi: 10.1016/j.ajpath.2015.01.031

Figure 4.

Figure 4

Early-onset osteoarthritis in Col5a1Δten/Δten mice. Representative histologic sections of tibial condyles in control and Col5a1Δten/Δten mice at postnatal day 30. Decalcified knee joint embedded in OCT. Frontal sections of the knee joint were stained with Safranin O and Fast green. A: The cartilage surface in the control mouse is smooth. B: The lateral surface of the tibia condyles in Col5a1Δten/Δten knee joint is covered with fibrous tissue and chronic inflammation cells. The cartilage erosion, chondrocyte death, and proteoglycan depletion indicate the onset of osteoarthritis in Col5a1Δten/Δten knee joint.