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. 2015 May;185(5):1471–1486. doi: 10.1016/j.ajpath.2015.01.029

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© 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Type III collagen (Col3) does not affect initial murine (4T1)–green fluorescent protein (GFP) cell adhesion and colonization in the lung. A: Col3 mRNA expression in lungs from young and aged mice relative to young Col3^+/+ lungs. B and C: 1.0 × 10⁶ 4T1-GFP cells were injected via the tail vein into young adult Col3^+/+ and Col3^+/− mice. After 24 hours, lungs were harvested and processed into single-cell suspensions. The percentage live [propidium iodine (PI)–negative] 4T1 cells (GFP positive) within the lung was quantified by flow cytometry. Data represent means ± SEM (A and C). n = 4 Col3^+/+ and n = 6 Col3^+/− (A, young mice); n = 3 Col3^+/+ and n = 3 Col3^+/− (A, aged mice); n = 10 to 12 per genotype (C). ^∗∗P < 0.01.