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. 2015 May;185(5):1471–1486. doi: 10.1016/j.ajpath.2015.01.029

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© 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Stromal type III collagen (Col3) density is heterogeneous within murine (4T1) tumors but is localized to the aligned matrix within tumors of Col3^+/− mice. A: mRNA expression of Col3 in 14-day tumors in Col3^+/+ and Col3^+/− mice. B: Images of Col3-stained tumors from Col3^+/+ and Col3^+/− mice showing the heterogeneity in the amount of Col3 staining but the consistent alignment of Col3-containing matrix in tumors of Col3^+/− mice. Representative images are from similar regions not containing tumor edge or necrosis. Boxed areas are enlarged in C. C: Images of Col3-stained tumors. n = 4 Col3^+/+ and Col3^+/− (A). Scale bar = 100 μm (B and C). Original magnifications: ×20 (B); ×60 (C).