Skip to main content
. 2015 May;185(5):1264–1274. doi: 10.1016/j.ajpath.2015.01.015

Figure 2.

Figure 2

A: Thrombosis score of the wild-type (WT) and Mrp14−/− mice in the three experiments, with significantly less thrombosis in the Mrp14−/− mice. B: Combined proteinuria results from the three experiments. C: Serum urea levels in the two animal groups: WT mice have significantly higher urea than Mrp14−/− mice. D: The number of CD68-positive cells per glomerular cross section in WT and Mrp14−/− animals. Medians are shown. E: Photomicrograph shows CD68 macrophage immunohistochemistry in Mrp14−/− mice, with few macrophages infiltrating the glomerulus. F: Photomicrograph shows the CD68 macrophage immunohistochemistry in WT mouse with severe disease. G: Infiltration of S100A8/A9 cells into the glomerulus of WT mice. H: Photomicrographs of glomeruli (periodic acid–Schiff stain) to demonstrate mouse glomerulus without nephrotoxic serum administration. I:Mrp14−/− mouse after nephrotoxic nephritis demonstrating a normal glomerulus. J: WT mouse demonstrating a thrombosed glomerulus and severe disease. ∗P < 0.05, ∗∗∗P < 0.001. Original magnification, ×400 (G). GCS, glomerular cross section.