Table 1. Levels of total protein, IL-6 and IL-1β in BALF after ventilation-induced lung injury and lung histopathology score.
| Parameter | Non-ventilated control | Ventilated groups |
|
|---|---|---|---|
| Low tidal volume | High tidal volume | ||
| Wet/dry ratio | 4.88±0.18 | 4.93±0.26 | 5.74±0.21* |
| Protein content (μg/μL) | 567±46 | 593±57 | 988±39* |
| BALF (pg/mL) | |||
| IL-6 | 2.42±0.13 | 2.44±0.32 | 7.32±0.24* |
| IL-1β | 53.63±5.26 | 53.55±6.63 | 139.95±9.37* |
| Plasma | |||
| IL-6 (pg/mL) | 1.70±0.23 | 1.67±0.21 | 2.08±0.11* |
| VILI-score | 0.30±0.10 | 0.50±0.15 | 3.5±0.5* |
Data are presented as mean ± SD (n=10 in all groups). *, P<0.001 vs. non-ventilated animals and animals ventilated with low tidal volume. BALF, bronchoalveolar lavage fluid; IL-1β, interleukin-1β; IL-6, interleukin-6; VILI, ventilator-induced lung injury.