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. Author manuscript; available in PMC: 2015 May 5.
Published in final edited form as: Virology. 2011 Jan 20;412(1):28–35. doi: 10.1016/j.virol.2010.12.054

Fig. 1.

Fig. 1

Schematic of the Ad chromosome. (A) The entire Ad5 chromosome is presented schematically. (B–D) The left end of the viral vector chromosomes are presented schematically. (B) The CMV promoter was inserted in the leftward orientation in the absence of a coding sequence. The RSV and UbC promoters were similarly introduced. (C) The structure of the CMV promoter directing ADPH expression is shown. (D) For viruses in which a gene was inserted and the E1A 243R coding sequence or E1A 243 coding sequence and E1B gene are retained, the insertion site is immediately downstream of the packaging sequence. The entire E1A promoter and enhancer (Hearing and Shenk, 1983) was used to direct E1A 243 expression, so the packaging sequence is reiterated.