Figure 4.

Induction and function of TREM-2 in lung macrophages during postviral lung disease. (A) Representative photomicrographs of TREM-2 plus F4/80 or Mac-3 immunostaining of lung sections from WT mice at 49 dpi with SeV or SeV-UV. Bar, 200 µm. (B) Representative photomicrographs of F4/80 plus IL-13 immunostaining of lung sections from WT and Trem2^−/− mice at 49 dpi with SeV-UV or SeV. Bar, 200 µm. (C) Levels of Il13, Arg1, and Chi3l3 mRNA in FACS-purified tissue monos, interstitial macs, and alveolar macs from WT and Trem2^−/− mice at 49 dpi with SeV or SeV-UV. Each value represents mean ± SEM for five mice and is representative of three experiments. * represents a significant increase from corresponding SeV-UV in WT value, and ** represents a significant decrease from corresponding SeV in WT value. All experimental data were verified in at least three independent experiments.