Table 2.
Comparison of chromosomal abnormalities * seen in patients with and without CNS involvement
| Variables | Total (n = 378) | Patients with CNS involvement (n = 19) | Patients without CNS involvement (n = 359) | Pvalue |
|---|---|---|---|---|
| Number (%) of patients | ||||
| Karyotype † | 0.378 | |||
| Favorable | 50 | 3(15.8) | 47(13.1) | |
| Intermediate | 264 | 15(78.9) | 249(69.4) | |
| Unfavorable | 64 | 1(5.3) | 63(17.5) | |
| t(8;21) | 34 | 1(5.3) | 33(9.2) | >0.999 |
| inv(16) | 16 | 2(10.5) | 14(3.9) | 0.189 |
| 11q23 abnormalities | 14 | 4(21.1) | 10(2.8) | 0.003 |
| -5/5q-‡ | 1 | 0(0) | 1(0.3) | >0.999 |
| -7/7q-‡ | 6 | 0(0) | 6(1.7) | >0.999 |
| t(7;11) | 4 | 0(0) | 4(1.1) | >0.999 |
| t(6;9) | 2 | 0(0) | 2(0.6) | >0.999 |
| +8‡ | 17 | 1(5.3) | 16(4.5) | 0.592 |
*Three hundred and seventy-eight patients had cytogenetic profiles at diagnosis. The remaining 17 patients did not have data of cytogenetic profiles because of inadequate metaphase cells for alalysis.
†Favorable, t(8;21), inv (16); unfavorable, -7, del(7q), -5, del(5q), 3q abnormality, complex abnormalities; Intermediate, normal karyotype and other abnormalities.
‡Includes only simple chromosomal abnormalities with 2 or fewer changes, but not those with complex abnormalities with 3 or more aberrations.
Abbreviation: CNS central nervous system.