Table 4.
Clinical characteristics and treatment outcomes of patients with initial CNS disease
| Patient | Age (years) | Gender | FAB | Leukocyte (/μL) | Cytogenetics | CNS Symptoms | Relapse | HSCT | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 43 | F | M1 | 1860 | CN | Seizure | Yes# | Yes | CR in 52.7 m |
| 2 | 21 | F | M2 | 15430 | t(8;21) | Blurred vision | No | Yes | CR in 41.4 m |
| 3 | 60 | F | M4 | 74390 | t(9;11)(p22;q23) | Dizziness | -∆ | No | Died in 3 m |
| 4 | 26 | F | M4 | 175900 | inv(16) | Headache | No | No | CR in 63.1 m |
| 5 | 72 | M | M4 | 168630 | inv(16) | Dizziness | No | No | CR in 40.9 m |
| 6 | 53 | F | M4 | 93340 | +8 | Paresthesias | No | No | Died in 4.3 m |
| 7 | 40 | M | M1 | 277250 | CN | Headache | No | No | CR in 58.1 m |
#This patient suffered from marrow relapse but not CNS relapse.
∆This patient suffered from induction death after standard induction chemotherapy.
Abbreviation: F, female; M, male; FAB, French-American-British; CN, normal karyotype; CNS, central nervous system; HSCT, hematopoietic, stem cell transplantation; CR, complete remission; m, month.