Table 3.
The performance of combinations of ZNF582 m and HPV tests in detecting CIN3+ in ASC
| Tests | Sensitivity (%) | Specificity (%) | Accuracy (%) | OR (95% CI) | P value |
|---|---|---|---|---|---|
| All ages (N = 242) | |||||
| ZNF582 m | 82.43 | 76.79 | 78.52 | 15.52 (7.73 to 31.18) | <0.001 |
| HPV-HR | 99.33 | 38.76 | 57.37 | - | <0.001 |
| HPV-16/18 | 66.22 | 88.10 | 81.41 | 14.50 (7.42 to 28.37) | <0.001 |
| ZNF582 m or HPV-16/18 | 89.19 | 70.24 | 76.03 | 19.47 (8.71 to 43.54) | <0.001 |
| ZNF582 m or HPV-16/18/52/58 | 95.95 | 48.81 | 63.22 | 14.79 (6.39 to 34.19) | <0.001 |
| ZNF582 m or HPV-HR | 99.33 | 34.02 | 54.10 | 76.84 (4.68 to 1262.62) | 0.002 |
| ZNF582 m and HPV-HR | 82.43 | 81.55 | 81.82 | - | <0.001 |
| ZNF582 m and HPV-16/18 | 59.46 | 94.64 | 83.88 | 25.91 (11.45 to 58.61) | <0.001 |
| Age under 30 (N = 31) | Sensitivity (%) | Specificity (%) | Accuracy (%) | OR (95% CI) | P value |
| ZNF582 m | 75.00 | 81.48 | 80.65 | 13.20 (1.12 to 154.92) | 0.043 |
| HPV-HR | 90.00 | 41.07 | 48.49 | - | 0.233 |
| HPV-16/18 | 75.00 | 92.59 | 90.33 | 37.50 (2.56 to 548.36) | 0.009 |
| ZNF582 m or HPV-16/18 | 75.00 | 77.78 | 77.42 | 10.50 (0.92 to 120.26) | 0.063 |
| ZNF582 m or HPV-HR | 90.00 | 37.50 | 45.46 | - | 0.274 |
| ZNF582 m and HPV-HR | 75.00 | 85.19 | 83.87 | 17.25 (1.42 to 210.12) | 0.028 |
| ZNF582 m and HPV-16/18 | 75.00 | 96.30 | 93.55 | 78.00 (3.81 to 1595.87) | 0.004 |
| Postmenopausal Women | Sensitivity (%) | Specificity (%) | Accuracy (%) | OR (95% CI) | P value |
| ZNF582 m | 88.89 | 69.77 | 75.41 | 18.46 (3.70 to 92.14) | <0.001 |
| HPV-HR | 97.37 | 48.86 | 63.49 | - | 0.001 |
| HPV-16/18 | 88.89 | 86.05 | 86.89 | 49.33 (8.97 to 271.23) | <0.001 |
| ZNF582 m or HPV-16/18 | 97.37 | 62.50 | 73.02 | - | <0.001 |
| ZNF582 m or HPV-HR | 97.37 | 44.32 | 60.32 | - | 0.001 |
| ZNF582 m and HPV-HR | 88.89 | 74.42 | 78.69 | 23.27 (4.60 to 117.81) | <0.001 |
| ZNF582 m and HPV-16/18 | 77.78 | 93.02 | 88.52 | 46.67 (9.27 to 234.86) | <0.001 |
P values determined by chi-square test or Fisher’s exact test; CI, confidence interval; HPV, human papillomavirus; HPV-HR, high-risk human papillomavirus; OR, odds ratio for CIN3 +; ZNF582 m, methylated ZNF582.