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. 2015 Apr 2;13:110. doi: 10.1186/s12967-015-0466-4

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© Foley et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Vorinostat treatment and preconditioning inhibits anchorage-independent OS cell growth. A/B: mHOS cells were treated with either 2 μM vorinostat or DMSO alone and allowed to grow for 4 days in AI conditions. Vorinostat treatment decreased the number of spheres (A), and resulted in a statistically significant decrease in cell viability (B). C/D: Adherent mHOS cells were pretreated for 12 days with either 2 μM vorinostat or DMSO alone and subsequently plated and allowed to grow for 4 days in AI conditions in the absence of drug. Vorinostat pretreatment decreased the number of spheres (C) and resulted in a significant decrease in cell viability (D). Asterisks indicate statistical significance (*p < 0.05, ***p < 0.001).