Scheme 2.
Synthesis of pyrimidines 4a,b and 5. R= CF3 (a), (CF2)2H (b). Conditions: i: 1,4-dioxane, NaOAc, Δ, 16–18 h; ii DMF, NaOAc, 80 °C, 24–26 h; iii: 1,4-dioxane, Et3N, Δ, 40 h.
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