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Theoretical structures of GRFT-tandemers. Griffithsin tandemers 2mGRFT, 2mGRFT3, 3mGRFT, and 4mGRFT are shown as models of monomeric units attached by flexible linker regions. The N and C termini (red and black, respectively) in a single mGRFT domain are approximately 10 Å apart, causing the individual domains in the tandemers to branch out. Each Gly-Thr-Gly linker (blue) is also approximately 10 Å long in its extended conformation.
