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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: ChemMedChem. 2014 Oct 21;10(1):107–115. doi: 10.1002/cmdc.201402358

Figure 2. A. GRL-05010A.

Figure 2

-bound X-ray structure of HIV-1 protease. The major orientation of the inhibitor is shown. The inhibitor carbon atoms are shown in green, water molecules are red spheres, and the hydrogen bonds are indicated by dotted lines. B. Nonbonded interactions of gem-difluorides with the carbonyl of Gly48 in the protease flap region are shown. These interactions are indicated with respective distances.