FIGURE 1.

Depiction of the ensembles of structures by conformational landscapes, with the location of minima, their depths and the heights of the barriers. Schematic representation of ensembles of structures for a globular, natively folded protein (A) and an intrinsically disordered protein (B). The description of a globular protein is based on an ensemble of structures clustered around a deep global minimum that can have substates in it (C) but represent basically the same topology, whereas the description of an IDP is based on a dynamic ensemble of different conformations represented by a collection of minima with similar depths (D).