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. 2015 May 5;6:311. doi: 10.3389/fpls.2015.00311

FIGURE 4.

FIGURE 4

Alternative splicing events in core clock genes. The scheme of the genes are shown on the top of each panel, the fully spliced isoforms encoding the full length proteins are indicated on the left side and alternative splice isoforms are indicated on the right side. (A) CCA1. The fully spliced isoform encoding full length CCA1 [designated CCA1α by Seo et al. (2012)] is indicated on the left. The splice isoform with intron 4 retained is shown on the right. It is predicted to encode a polypeptide terminating at the PTC within intron 4, thus comprising only the DNA-binding Myb domain, or the CCA1β polypeptide comprising only the dimerization domain (Seo et al., 2012). (B) LHY. The splice isoform with alternative splicing at intron 5 leading to inclusion of exon 5a including a PTC is shown on the right. (C) PRR9. The splice isoform retaining intron 3 including a PTC is shown on the right (black broken arrow). The spliced isoform with additional eight nucleotides at exon 2 due to the use of an alternative 5′ splice site entailing a frame shift is shown on the right at the bottom (red broken line). This splice isoform is elevated in prmt5.