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Insulin-like growth factor 1 receptor (IGF-1R)-insulin receptor (IR) reciprocal interactions: signal transduction from extracellular stimuli such as IGF-1, IGF-2 and insulin to intracellular pathways is mediated through IGF-1R, IR and IGF-1R/IR heterodimers. Furthermore, IR activity may be up-regulated in a compensatory manner upon inhibition of IGF-1R.
