Table 4.

Pulmonary-epithelioid hemangioendothelioma histological and cytologic features.

	Solitary or multiple pulmonary nodules
Macroscopical appearance
Diameter	>5 cm
Consistency	Rubbery or cartilage-like
Cut surface	From grey-white to yellow-brown Semi- or normotranslucency
Microscopical appearance
Periphery of the nodules	Hypercellular
Centre of the nodules	Hypocellular Coagulative necrosis Hyalinization Calcification Ossification
Cytoplasm	Abundant
Nucleus	Round or oval
Atypia	Low-grade, one third marked
Mitotic activity	Scarce, one third notable (>10 mitosis/HPF)
Increased risk of metastasis
	Marked nuclear atypia Notable mitotic activity (>10 mitosis/HPF) Necrosis

HPF, high-power fields.