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. 2015 May 5;9:159. doi: 10.3389/fnins.2015.00159

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Copyright © 2015 van Opstal, Westerink, Teeuwisse, van der Geest, van Furth and van der Grond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative BOLD fMRI signal change of the hypothalamus in response to glucose. The hypothalamic BOLD response showed a decrease of 1.4% in patients and a decrease of 1.0% in controls after glucose ingestion, no significant differences in response were found between groups. Segmentation of the hypothalamus into four subdivisions showed similar results. (A) Total hypothalamus, (B) lower anterior hypothalamus (LAH), (C) lower posterior hypothalamus (LPH), (D) upper anterior hypothalamus (UAH), (E) upper posterior hypothalamus (UPH).