Table 1.
Patient demographic and baseline characteristics – discovery cohort.
| PD (n = 36) | MSA (n = 27) | Controls (n = 57) | |
|---|---|---|---|
| Age in years (SD)b | 60.1 (10.4) | 62.6 (9.0) | 57.0 (11.5) |
| Number of males (%) | 22 (61.1) | 15 (55.6) | 37 (64.9) |
| Years of follow-up (range) | 5.5 (0–9.2) | 2.9 (0–7.9) | N/A |
| NFL (ng/L) | 1350 (915) | 4548 (3206) | 1503 (619) |
| FLT3L (ng/L) | 38.4 (11.9) | 39.3 (12.4) | 47.8 (14.3) |
| t-tau (ng/L) | 242 (190) | 335 (164) | 251 (110) |
| Disease duration, months (range)c | PD (n = 28) | MSA (n = 14) | p-Valuea |
| 43.8 (6–158) | 43.7 (8–96) | p = 0.508 | |
| Disease severityc | PD (n = 32) | MSA (n = 14) | p-Valuea |
| H&Y | 2.0 (0.60); n = 32 | 2.7 (1.2); n = 14 | p = 0.014 |
| UPDRS; mean (SD) | 30.3 (11.5); n = 27 | 32.5 (16.7); n = 14 | p = 0.627 |
| ICARS; mean (SD) | 2.9 (4.8); n = 20 | 12.1 (9.5); n = 9 | p = 0.020 |
| Cognitive function | PD (n = 28) | MSA (n = 14) | p-Valuea |
| MMSE; mean (SD) | 28.5 (1.6) | 27.5 (3.5) | p > 0.05 |
SD, standard deviation; H&Y, Hoehn and Yahr score; ICARS, International Cooperative Ataxia Rating Scale; UPDRS, unified Parkinson’s disease rating scale; N/A, not applicable.
aStudent’s t-test p-values for PD versus MSA.
bAt time of lumbar puncture.
cAt time of inclusion.