Table 1.

Likelihood Ratio Test Statistics for Models of Variable Selective Pressure among Sites (codon frequency model:F3x4)

Gene/Selection Model	N Species	−2ΔLn L	P Value	% of Sites (average dN/dS)
OAS1
M1a versus M2a
Primates	17	56.91	4.40 × 10−13	20.0 (2.9)
Chiroptera	7	32.49	8.77 × 10−8	7.0 (6.4)
M7 versus M8
Primates	17	62.14	3.22 × 10−14	23.6 (2.7)
Chiroptera	7	33.10	6.50 × 10−8	7.0 (6.3)
OAS2
M1a versus M2a
Primates	16	63.19	1.89 × 10−14	7.9 (3.3)
M7 versus M8
Primates	16	89.44	3.78 × 10−20	12.6 (2.7)
MB21D1
M1a versus M2a
Primates	16	37.05	8.99 × 10−9	8.9 (3.2)
Chiroptera	6	12.49	0.002	35.1 (2.0)
M7 versus M8
Primates	16	45.89	1.08 × 10−10	11.4 (2.9)
Chiroptera	6	13.10	0.001	35.0 (2.0)
RNASEL
M1a versus M2a
Primates	21	41.32	1.06 × 10−9	6.0 (3.2)
Chiroptera	7	44.19	2.53 × 10−10	9.8 (4.2)
M7 versus M8
Primates	21	56.06	6.70 × 10−13	9.5 (2.6)
Chiroptera	7	44.13	2.61 × 10−10	10.3 (4.1)
TMEM173
M1a versus M2a
Primates	17	6.62	0.04	3.3 (2.5)
Chiroptera	7	32.91	7.14 × 10−8	16.9 (4.1)
M7 versus M8
Primates	17	7.44	0.02	11.3 (1.8)
Chiroptera	7	33.32	5.81 × 10−8	16.8 (4.1)

Note.—M1a is a nearly neutral model that assumes one ω class between 0 and 1 and one class with ω = 1; M2a (positive selection model) is the same as M1a plus an extra class of ω > 1; M7 (null model) assumes that 0 < ω < 1 is beta distributed among sites in ten classes; M8 (selection model) has an extra class with ω ≥ 1; 2ΔLn L, twice the difference of the natural logs of the maximum likelihood of the models being compared; P Value, P value of rejecting the neutral models (M1a or M7) in favor of the positive selection model (M2a or M8); % of sites (average dN/dS), estimated percentage of sites evolving under positive selection by M8 and M2a (dN/dS for these codons).