. 2015 Mar 9;7(4):1016–1032. doi: 10.1093/gbe/evv046

Table 2.

Positively Selected Sites in the Human, Chimpanzee, and Gorilla Lineages

Gene	Lineage	Codon	Ancestral AA	Derived AA	Pr^a	DAF^b	Other Methods^c
OAS1
	Human	54^d	Arg	Cys	0.868	1	MEME–BEB
		127	Asp	Gly	0.928	1
		279^d	Glu	Lys	0.885	1	BEB
		292^d	Arg	Thr	0.976	1	MEME–BEB
		350	Asp	Asn	0.963	1
	Chimpanzee	24^d	Thr	Lys	0.988	1
		28^d	Met	Lys	0.990	1	BEB
		47^d	Arg	Gln	0.982	1
		54^d	Arg	His	0.972	1	MEME–BEB
		242^d	Arg	Gln	0.834	0.62	MEME–BEB
		246^d	Lys	Glu	0.845	0.60	BEB
		248^d	His	Asp	0.847	0.60	BEB
		254^d	Gly	Glu	0.842	0.61
		292^d	Arg	Thr/Glu	0.941	0.62/0.38	MEME–BEB
		355	Trp	Stop^e	0.775	0.62
	Gorilla	54^d	Arg	Cys	0.818	1	MEME–BEB
		69	Thr	Ala	0.823	1	BEB
		127	Asp	Gly	0.846	1
		175	Glu	Lys	0.940	1	MEME–BEB
		179	Asp	Tyr	0.936	1	MEME–BEB
		242^d	Arg	Gln	0.807	1	MEME–BEB
		279^d	Glu	Lys	0.850	1	BEB
OAS2
	Chimpanzee	216	Asp	Asn	0.834	1
		253	Glu	Lys	0.828	1	BEB
	Gorilla	361	Cys	Phe	0.869	1	BEB
		369	Ala	Thr	0.867	1
		412	Val	Ile	0.799	1
		443	Trp	Ser	0.767	1	MEME–BEB
OAS3
	Human	446	Arg	His	0.828	1
		514	Gly	Ser	0.860	1	MEME–BEB
		620	Arg	Gly	0.837	1
	Chimpanzee	347	Arg	Cys	0.794	1	MEME–BEB
		373	Asn	Ser	0.773	0.96	MEME–BEB
	Gorilla	18	Arg	Ser	0.870	1
		23	Lys	Thr	0.873	1
		44	Gly	Ala	0.818	1
OASL
	Human	179	Glu	Lys	0.857	1
		311	His	Leu	0.857	1
		432	Pro	Ser	0.856	1
	Chimpanzee	36	Ala	Thr	0.799	1
		117	Asp	Asn	0.759	1
		507	Gly	Arg	0.839	1
MB21D1
	Human	339	Pro	Arg	0.909	1	MEME
		341	Lys	Gln	0.910	1
	Chimpanzee	399	Asn	Ile	0.854	1
		448	Gln	Glu	0.910	1
		477	Thr	Ile	0.912	1
		494	Asn	Asp	0.894	1
	Gorilla	339	Pro	Arg	0.931	1	MEME
		341	Lys	Gln	0.932	1
		350	Lys	Arg	0.900	1	BEB
		459	Asp	Gln	0.898	1	BEB
		493	Ser	Arg	0.774	1
RNASEL
	Human	3	Thr	Ser	0.823	1
		178	Glu	Lys	0.816	1	BEB
		214	His	Asp	0.928	1	BEB
		216	Arg	Ser	0.928	1	MEME
		287	Glu	Lys	0.802	1	MEME
		319	Phe	Val	0.781	1	MEME–BEB
	Chimpanzee	28	Leu	Ser	0.987	1
		36	Glu	Gly	0.997	1	MEME–BEB
		40	Leu	Gln	0.998	1	MEME
		47	Gly	Asp	0.995	1	BEB
		71	Arg	Lys	0.985	1	MEME
		73	Asp	Glu	0.982	1	MEME
		734	Ser	Cys	0.806	1
TMEM173
	Chimpanzee	78	Arg	Trp	0.759	1

^aPosterior probability of γ ≥ 1 as detected by gammaMap.

^bDerived allele frequency.

^cOther methods that identified the same codon as positively selected.

^dSite described as long-term balancing selection target (see text).

^eTo perform GammaMap analyses, the STOP codon was substituted with a different codon.