Table 2.

Identities of 2-DGE-separated mitochondrial proteins from PBMCs mitochondrial lysates. Ratio=[averaged spot abundance in FRDA’s gels]/[averaged spot abundance in NHV’s gels].

Gene	Protein name	Access #	Theoretical		Normal PBMCs		FRDA PBMCs		Ratio	p-value
			p/	Mr	Average (n=)	SD	Average (n=)	SD
HSPD1	Heat shock protein 60 kDa	P10809	5.7	61.1	1.278	0.179	0.549	0.139	0.4	0.01
HSPA9B	Heat shock protein 70 kDa	P38646	5.9	73.7	0.514	0.020	0.196	0.098	0.4	0.01
ATP5A1	ATP synthase subunit alpha	P25705	9.2	60.0	0.874	0.556	0.366	0.004	0.4	0.19
ALDH2	Aldehyde dehydrogenase	P05091	6.6	56.4	0.061	0.016	0.035	0.009	0.6	0.07
ATP5A1	ATP synthase subunit alpha	P25705	9.2	60.0	0.197	0.049	0.118	0.049	0.6	0.12
GLUD1	Glutamate dehydrogenase 1	P00367	7.7	61.4	0.197	0.049	0.118	0.049	0.6	0.12
FH	Fumarase	P07954	6.9	50.2	0.040	0.014	0.029	0.022	0.7	0.50
ATP5B	ATP synthase subunit beta	P06576	5.3	56.6	1.663	0.150	1.315	0.697	0.8	0.45
PRDX3	Peroxiredoxin 3	P30048	7.7	27.7	0.278	0.106	0.221	0.108	0.8	0.55
PHB	Prohibitin	P35232	5.6	29.8	0.217	0.094	0.189	0.056	0.9	0.69
HSD17B	HSD17B10 Hydroxysteroid (17-beta) dehydrogenase	Q99714	7.7	26.9	0.110	0.004	0.105	0.020	1.0	0.67
PRDX3	Peroxiredoxin 3	P30048	7.7	27.7	0.088	0.046	0.092	0.080	1.1	0.94
C1QBP	Complement component 1 Q subcompo	Q07021	4.7	31.4	0.146	0.063	0.177	0.092	1.2	0.65
SOD2	Superoxide dismutase [Mn]	P04179	8.4	24.7	0.359	0.010	0.447	0.207	1.2	0.50
ACO2	Aconitase	Q99798	7.4	85.4	0.526	0.009	0.793	0.512	1.5	0.42
ATP5B	ATP synthase subunit beta	P06576	5.3	56.6	0.068	0.013	0.124	0.092	1.8	0.36
ATP5B	ATP synthase subunit beta	P06576	5.3	56.6	0.499	0.172	0.918	0.288	1.8	0.10
ATP5B	ATP synthase subunit beta	P06576	5.3	56.6	0.525	0.234	1.016	0.471	1.9	0.18
MRPL55	Mitochondrial ribosomal protein L55 isof	Q7Z7F7	11.0	18.9	0.073	0.036	0.152	0.161	2.1	0.45
NDUFA6	NADH dehydrogenase (ubiquinone) 1	P56556	10.0	15.1	0.038	0.011	0.152	0.087	4.0	0.09