Table 4.
Predictors of overall survival for EOC within NCDB cohort (1998–2002).
| Risk factor | N | % | Unadjusted HR | 95% CI
|
Adjusted HR | 95% CI
|
||
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | |||||
| Patient characteristics | ||||||||
| Age (years) | ||||||||
| <60 | 21,087 | 42.89 | Referent | Referent | ||||
| 60–75 | 18,610 | 37.86 | 1.750 | 1.704 | 1.796 | 1.282 | 1.240 | 1.325 |
| >75 | 9463 | 19.25 | 3.267 | 3.155 | 3.383 | 2.095 | 1.999 | 2.195 |
| Race | ||||||||
| Whites | 43,995 | 89.49 | Referent | Referent | ||||
| Non-Whites | 4568 | 9.29 | 1.232 | 1.167 | 1.301 | 1.204 | 1.149 | 1.261 |
| Unknown | 597 | 1.21 | 1.012 | 0.908 | 1.127 | 1.108 | 1.001 | 1.227 |
| Payer information | ||||||||
| Private insurance | 9680 | 19.69 | Referent | Referent | ||||
| Medicare/medicare supplements | 19,371 | 39.40 | 2.155 | 2.082 | 2.230 | 1.236 | 1.186 | 1.289 |
| Managed care/TRICARE/military | 14,221 | 28.93 | 1.026 | 0.988 | 1.065 | 1.019 | 0.982 | 1.058 |
| Medicaid/federal insurance programs/public health service | 1949 | 3.96 | 1.481 | 1.385 | 1.584 | 1.263 | 1.177 | 1.355 |
| Not insured— self pay | 1744 | 3.55 | 1.385 | 1.281 | 1.498 | 1.276 | 1.171 | 1.391 |
| Insurance status unknown | 2195 | 4.47 | 1.438 | 1.323 | 1.562 | 1.119 | 1.001 | 1.252 |
| Adherence to NCCN guidelines for Rx | ||||||||
| Yes | 21,286 | 43.30 | Referent | Referent | ||||
| No | 27,874 | 56.70 | 1.322 | 1.284 | 1.361 | 1.403 | 1.362 | 1.446 |
| Tumor characteristics | ||||||||
| Tumor stage | ||||||||
| Stage I | 8625 | 17.54 | Referent | Referent | ||||
| Stage II | 4042 | 8.22 | 2.402 | 2.208 | 2.613 | 2.131 | 1.963 | 2.313 |
| Stage III | 21,888 | 44.52 | 6.399 | 6.010 | 6.812 | 5.881 | 5.516 | 6.270 |
| Stage IV | 14,605 | 29.71 | 11.785 | 11.074 | 12.542 | 9.476 | 8.893 | 10.098 |
| Tumor grade | ||||||||
| Well/moderately differentiated | 13,244 | 26.94 | Referent | Referent | ||||
| Poorly/undifferentiated/anaplastic | 25,538 | 51.95 | 1.786 | 1.724 | 1.850 | 1.200 | 1.159 | 1.242 |
| Missing | 10,378 | 21.11 | 3.114 | 2.987 | 3.246 | 1.472 | 1.416 | 1.531 |
| Facility characteristics | ||||||||
| Facility type | ||||||||
| Academic/research cancer program | 20,987 | 42.69 | Referent | Referent | ||||
| Comprehensive community cancer program | 22,087 | 44.93 | 1.124 | 1.080 | 1.169 | 1.020 | 0.980 | 1.061 |
| Community cancer program | 6086 | 12.38 | 1.256 | 1.190 | 1.325 | 1.054 | 0.996 | 1.114 |
| Average hospital ovarian cancer case volume/year (1998–2002) | ||||||||
| 1–6 cases/year | 12,398 | 25.22 | Referent | Referent | ||||
| 7–14 cases/year | 12,200 | 24.82 | 0.848 | 0.813 | 0.885 | 0.955 | 0.912 | 1.000 |
| 15–25 cases/year | 12,146 | 24.71 | 0.785 | 0.751 | 0.821 | 0.920 | 0.876 | 0.966 |
| ≥26 cases/year | 12,416 | 25.26 | 0.738 | 0.702 | 0.775 | 0.910 | 0.858 | 0.964 |
| Total | 49,160 | 100.00 | ||||||
Hazard Ratios Bolded for p < 0.05.