Table 8.
Results for Lobular Carcinoma
| Histopathologya | |||||
|---|---|---|---|---|---|
| OSNAb | Macro | Micro | ITC | Negative | Total |
| ++ | 10 | 3 | 0 | 1 | 14 |
| + | 1 | 1 | 0 | 0 | 2 |
| − | 0 | 2 | 4 | 62 | 68 |
| Total | 11 | 6 | 4 | 63 | 84 |
OSNA indicates the One Step Nucleic Acid Amplification Breast Cancer System; Macro, macrometastasis; Micro, micrometastasis; ITC, isolated tumor cells.
a
Lobular carcinoma deposits in sentinel lymph nodes were analyzed either by reference pathology in a central pathology laboratory or by using the OSNA Breast Cancer System. Criteria for macrometastasis, micrometastasis, ITCs, or negative findings followed American Joint Committee on Cancer Staging Manual (6th edition) guidelines.
b
OSNA results were classified as ++ (macrometastasis), + (micrometastasis), or − (negative), as determined by a pre-established cutoff number of cytokeratin 19 messenger RNA copies.