Table 1.

Notations and symbols of the methodology

Notation	Size	Meaning
Dk	n×n	The k-th drug similarity matrix
Sl	m×m	The l-th disease similarity matrix
U	n×CD	Drug cluster assignment matrix
V	m×CS	Disease cluster assignment matrix
Λ	CD×CS	Drug-disease cluster relationship matrix
R	n×m	Observed drug-disease association matrix
Θ	n×m	Densified estimation of R
ω	Kd×1	Drug similarity weight vector
π	Ks×1	Disease similarity weight vector