Table 2.
Top 10 drugs for diseases Alzheimer’s Disease (AD) and Systemic Lupus Erythematosus (SLE) based on DDR predictions
| (a) Top 10 drugs predicted for AD | (b) Top 10 drugs predicted for SLE | ||||
|---|---|---|---|---|---|
|
| |||||
| Drug | Prediction Score | Clinical Evidence? | Drug | Prediction Score | Clinical Evidence? |
| Selegiline* | 0.7091 | — | Desoximetasone | 0.7409 | No |
| Carbidopa | 0.6924 | No | Azathioprine* | 0.7269 | — |
| Amantadine | 0.6897 | No | Leflunomide | 0.7078 | Yes |
| Procyclidine | 0.6826 | No | Fluorometholone | 0.7054 | No |
| Valproic Acid* | 0.6745 | — | Triamcinolone* | 0.6862 | — |
| Metformin | 0.6543 | Yes | Beclomethasone | 0.6522 | No |
| Bexarotene | 0.6426 | Yes | Etodolac | 0.6445 | No |
| Neostigmine | 0.6385 | No | Hydroxychloroquine* | 0.6374 | — |
| Galantamine* | 0.6348 | — | Nelfinavir | 0.6371 | Yes |
| Nilvadipine | 0.6159 | Yes | Mercaptopurine | 0.6150 | No |
*
denotes the drug is known and approved to treat the disease