Table 4.

List of drugs included in preliminary analysis, with their most common adverse reactions, frequency of incidence in adults, as listed in the FDA’s online drug library.²² The last column shows the most frequent adverse effects extracted from the Twitter data using our automated system. Effects found in both are highlighted in bold.

Drug Brand/Generic Name	Primary Indications	Documented Adverse Effects (no order)	Adverse Effects Found in Tweets (Frequency)
Seroquel/Quetiapine	Schizophrenia, Bipolar I Disorder: manic episodes, Bipolar Disorder	somnolence, dry mouth, headache, dizziness, asthenia, constipation, fatigue	somnolence (22.2%), abnormal dreams (9.6%), feel like a zombie (8.1%), weight gain (6.6%), restless leg syndrome (6.6%), increased appetite (5.9%), sleep paralysis (2.9%), dizziness (2.2%), psychosis (2.2%), tremors (2.2%)
Effexor/venlafaxine	Major Depressive Disorder (MDD)	nausea, headache, somnolence, dry mouth, dizziness	withdrawal syndrome (21.3%), insomnia (11.1%), headache (4.3%), malaise (4.3%), abnormal dreams (4.3%), nausea (3.4%), shaking (3.4%), fatigue (3.4%)
Vyvanse	ADHD	decreased appetite, insomnia, dry mouth, diarrhea, nausea	insomnia (38.2%), OCD (9.3%), anger (5.6%), heart racing (5.6%), depression (3.6%), psychosis (3.6%), headache (3.6%), feel weird (3.6%)
Paxil/Paroxetine	MDD, Obsessive Compulsive Disorder (OCD), Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder (GAD), PTSD	nausea, somnolence, abnormal ejaculation, asthenia, tremor, insomnia, sweating	withdrawal syndrome (27.7%), weight gain (12.8%), depression (8.5%), headache (6.4%), somnolence (6.4%), allergic (6.4%), feel sick (6.4 %), emotional (6.4%)
Prozac/Fluoxetine	MDD, OCD, Bulimia Nervosa Panic Disorder	nausea, headache, insomnia, nervousness, anxiety, somnolence	somnolence (22.2%), withdrawal syndrome (8.9%), feeling ill (8.9%), abnormal dreams (6.7%), suicidal thoughts (6.7%), tremors (6.7%), allergic reaction (4.4%)
Lamictal lamotrigine	Epilepsy, Bipolar Disorder	vomiting, coordination abnormality, dizziness, rhinitis, dyspepsia, nausea, headache, diplopia, ataxia, insomnia, fatigue, back pain	insomnia (17.9%), rash (12.8%), lethargy (7.7%), joint pain (5.1%), feel like a zombie (5.1%), feel sick (5.1%)
Zyprexa/olanzapine	Schizophrenia, Bipolar I Disorder	dizziness, constipation, personality disorder, weight gain, akathisia, somnolence, dry mouth, asthenia, dyspepsia	weight gain (40.0%), somnolence (11.4%), increased appetite (8.6%), dependence (5.7%)
Humira	Rheumatoid Arthritis, Juvenile Idiopathic Arthitis, Psoriatic Arthitis, Crohn’s Disease, Ulcerative Colitus, Plaque Psoriasis	upper respiratory infection, rash, headache, sinusitis, accidental injury	somnolence (24%), feel sick (8%), palpitations (8%), ache/pains (8%), joint pain (4%), headache (4%), rash (4%), respiratory disorder (4%)
Cymbalta/Duloxetine	MDD, GAD, Diabetic Peripheral Neuropathy, Fibromyalgia, Chronic Muscoskeletal Pain	nausea, headache, dry mouth, fatigue, somnolence	withdrawal syndrome (16.3%), fatigue (14.0%), somnolence (7.0%), dizziness (7.0%), dry mouth (4.7%), depression (4.7%), rash (4.7%), migraine (4.7%)
Trazodone	MDD	somnolence, headache, dry mouth, dizziness, nausea	somnolence (24.3%), abnormal dreams (16.2%), hangover effect (8.1%), headache (5.4%), insomnia (5.4%), withdrawal syndrome (5.4%)