Fig. 9.

Typical sequence pattern including distal and proximal residues found in representatives of the peroxidase–peroxygenase superfamily. Color scheme: blue highest similarity (93% conservation), green moderate similarity (67%), yellow low similarity (33%). In addition the active site architectures of enzymes from Caldariomyces fumago and Agrocybe aegerita are depicted. Note that both proteins have a cation-binding site in the heme periphery. Abbreviations of sequence names are explained in Supplem. Table 1 and they correspond with the nomenclature of PeroxiBase (http://peroxibase.toulouse.inra.fr). Secondary structure elements for AaeAPO structure are given above the alignment.